1. Home
  2. Understanding MPNs
  3. Why and how did my MPN arise? — Expert Video
Understanding MPNs — Animation
Understanding MPNs — Animation
Understanding MPNs — Slide Show
Understanding MPNs — Slide Show
Expert Videos
What are myeloproliferative neoplasms (MPNs)?
1. What are myeloproliferative neoplasms (MPNs)?
Why and how did my MPN arise?
2. Why and how did my MPN arise?
How are MPNs diagnosed?
3. How are MPNs diagnosed?
What are the signs and symptoms of MPNs?
4. What are the signs and symptoms of MPNs?
What are the risks of living with an MPN?
5. What are the risks of living with an MPN?
What are the expectations of living with an MPN?
6. What are the expectations of living with an MPN?
How are MPNs treated?
7. How are MPNs treated?
Patient Videos
Ben: How did you find out you had a myeloproliferative neoplasm (MPN)?
8. Ben: How did you find out you had a myeloproliferative neoplasm (MPN)?
Ben: What challenges and successes have you had with your MPN treatment?
9. Ben: What challenges and successes have you had with your MPN treatment?
Ben: What advice do you have for others on their journey with MPN?
10. Ben: What advice do you have for others on their journey with MPN?

Why and how did my MPN arise? — Expert Video

In this video, Dr. Jyoti Nangalia explains that myeloproliferative neoplasms (MPNs) develop when a mutation occurs in a blood stem cell, causing it to produce too many blood cells. Most cases are linked to one of three key gene mutations: JAK2, CALR, or MPL. These mutations can appear early in life and grow slowly over decades, often without symptoms at first. Dr. Nangalia also discusses how a combination of genetics, environment, and possibly lifestyle may influence why these mutations occur or progress in some individuals but not others.

  • Share with family and friends:

Click here to take our SURVEY
Your feedback is important to us! We will use your feedback to develop future areas of content about myeloproliferative neoplasms which will help other patients, caregivers, and families.

Understanding MPNs — Animation
Understanding MPNs — Animation
Understanding MPNs — Slide Show
Understanding MPNs — Slide Show
Expert Videos
What are myeloproliferative neoplasms (MPNs)?
1. What are myeloproliferative neoplasms (MPNs)?
Why and how did my MPN arise?
2. Why and how did my MPN arise?
How are MPNs diagnosed?
3. How are MPNs diagnosed?
What are the signs and symptoms of MPNs?
4. What are the signs and symptoms of MPNs?
What are the risks of living with an MPN?
5. What are the risks of living with an MPN?
What are the expectations of living with an MPN?
6. What are the expectations of living with an MPN?
How are MPNs treated?
7. How are MPNs treated?
Patient Videos
Ben: How did you find out you had a myeloproliferative neoplasm (MPN)?
8. Ben: How did you find out you had a myeloproliferative neoplasm (MPN)?
Ben: What challenges and successes have you had with your MPN treatment?
9. Ben: What challenges and successes have you had with your MPN treatment?
Ben: What advice do you have for others on their journey with MPN?
10. Ben: What advice do you have for others on their journey with MPN?
 

This educational activity has been developed by MPN Research Foundation in collaboration with Mechanisms in Medicine Inc.

This activity is supported by independent educational grants from Disc Medicine, Incyte, Merck and PharmaEssentia.

Thank you to the funders of You And MPN. All content is developed independently by MPN Research Foundation and Mechanisms in Medicine Inc., in collaboration with an Expert Faculty group; funders are allowed no influence on the content of You And MPN: Animated Patient® Guide to Myeloproliferative Neoplasms.

Disclaimer: The information provided is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always consult your doctor about any questions you may have regarding a medical condition. The visuals provided are meant to be representations only. No specific brand is being promoted or endorsed.

Copyright © Mechanisms in Medicine Inc. All rights reserved.

This website is part of the Animated Patient® series developed by Mechanisms in Medicine Inc., to provide highly visual formats of learning for patients to improve their understanding, make informed decisions, and partner with their healthcare professionals for optimal outcomes.