Dr. Gabriela Hobbs from the Mass General Brigham Cancer Institute explains the
risks and complications associated with
essential thrombocythemia (
ET). Patients with ET can be at risk for both
blood clots and, paradoxically,
bleeding—especially if platelet counts are very high. While progression to
myelofibrosis occurs in about 10% of patients and
acute leukemia in less than 5%, most people live long-term with ET. Dr. Hobbs emphasizes the importance of tracking symptoms, communicating with healthcare providers, and managing cardiovascular risk factors through regular activity, a balanced diet, and overall healthy lifestyle choices to reduce complications and support quality of life.
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