Assistant Professor of Medicine at the University of Chicago, Dr. Anand Patel, discusses
emerging therapies that are shaping the
future of myelofibrosis (
MF)
care. Dr. Patel explains that several new drugs are being studied in clinical trials, including
combination approaches that pair
novel agents with JAK inhibitors to improve spleen size reduction and symptom control (such as
pelabresib used with
ruxolitinib). He also discusses treatments for patients whose MF has not responded to prior therapy (including
imetelstat) and highlights ongoing research targeting
new disease pathways (such as
nuvisertib). Overall, he emphasizes a move toward more personalized treatment strategies, including how established JAK inhibitors like
momelotinib,
pacritinib, and
fedratinib may be best combined with newer therapies, rather than relying on a one-size-fits-all approach.
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