What new therapies are being developed for myelofibrosis (MF)? — Expert Video

Assistant Professor of Medicine at the University of Chicago, Dr. Anand Patel, discusses emerging therapies that are shaping the future of myelofibrosis (MF) care. Dr. Patel explains that several new drugs are being studied in clinical trials, including combination approaches that pair novel agents with JAK inhibitors to improve spleen size reduction and symptom control (such as pelabresib used with ruxolitinib). He also discusses treatments for patients whose MF has not responded to prior therapy (including imetelstat) and highlights ongoing research targeting new disease pathways (such as nuvisertib). Overall, he emphasizes a move toward more personalized treatment strategies, including how established JAK inhibitors like momelotinib, pacritinib, and fedratinib may be best combined with newer therapies, rather than relying on a one-size-fits-all approach.

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